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Genotoxicity Assessment
fast, easy and economical
Screening fast and easy
genotoxicity screening and individual medication
in cancer therapy
Introduction
The human being is in contact with up to 70.000 chemicals in daily use (EINECS database), varying from industrial chemicals (such as solvents, petrochemicals), consumer chemicals (such as pharmaceuticals, personal-care products) to biocides. Especially the chemicals out of the class of genotoxic chemicals can harm the human by causing mutation to the genome and may cause cancer.
To assess the risk of chemicals and chemical mixtures or predict the effectivity of medicamentation Nova Palm developed an in vitro bioassay as high throughput screening method by using the comet assay method.
The Technology
Screening large numbers of samples in pharmaceutics, environmental screenings assessments or in medicine is very cost intense. We developed a new tool which allows to screen a large number of samples in the same time. So one person can test up to 40 different samples a day instead of max. 2-3 by using the conventional comet assay.
The Comet Assay - the fastest in vitro bioassay
The comet assay also known as single cell gel electrophoresis in vitro bioassay is widely used for pharmaceutics, medical and screening assessments.
The comet assay as an indicator test for negative effects to the genome of human cells evaluates the cancer risk of mixtures or single components by measuring the destruction of the DNA of each cell in form of a comet before a mutation takes place.
New possibilities for an healthier life
The new high throughput assay allows screening measurements of a large number of samples in different areas which could not be addressed so far because of economical reasons.
Environmental screening
The screening of a large numbers of samples is especially necessary for the environmental screening. The high throughput comet assay offers now an easy, fast and cheap approach to investigate the cancerogenous risk of river, lakes, air, etc. caused by pollution of the industry
Genotoxicity measurement
Up to now it was not possible to screen the genotoxic risk for example of pharmaceutic candidates in an early stage of the development process. By using the high throughput version of the comet assay it is possible to screen all candidates in an early stage (cytotoxic and genotoxic) because all procedures are done for all samples at the same time.
Individual cancer therapy
Effective medicamentation is very important to avoid any site effects especially in cancer treatment. T o minimize the site effects of the chemostatics therapy for the human being an individual designed therapy is necessary because each cancer cell reacts individual. The new comet assay enables now a prior test before the medicamentation to evaluate the suitability of the chosen chemostatic treatment.
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